|
The
HIPPO Tumor Suppressor Pathway:
A Brainstorming Workshop
The aim of the gathering is to integrate the current knowledge of
the Hippo pathway and to understand when the activation of this pathway
results in proliferative and when in apoptotic signals
22
April 2009
08:45 Welcome
Prof. Paola MUTI, IRE Scientific Director
S.E. Mons. Sergio PINTOR, President, Nicola's Foundation
09:00 - 10:00 Introduced and chaired by Dr. Giovanni Blandino
Dr. Marius SUDOL "From Src oncogene to WW domain: The
role of YAP in the mammalian Hippo pathway"
Dr. Mike YAFFE "TAZ: A Mesenchymal Stem Cell Modulator
of Cell Differentiation Moonlights as a Promoter of Tumor Cell Metastasis"
10:00 - 10:30 Short
talk speakers,
chaired by
Dr. Marius Sudol & Dr. Mike Yaffe:
Dr. Kieran HARVEY "Transcriptional output of the Salvador/Warts/Hippo
pathway is controlled in distinct fashions in Drosophila melanogaster,
and human breast epithelial cells"
Dr. Iain FARRANCE "Casein Kinase 2 (CK2) Interacts With
and Regulates TEF-1 (TEAD1) DNA Binding and Transcriptional Activity"
10:30-11:00
Coffee Break
11:00 - 11:30 Introduced
and chaired by Dr. Yosef Shaul
Dr. Georg HALDER "Boundaries of Dachsous Cadherin activity
modulate the Hippo signaling pathway to induce cell proliferation"
11:30-13:00 Short
talk speakers,
chaired by
Dr. Georg Halder & Dr. Yosef Shaul
Dr. Linda PARSONS "Apico-basal polarity complexes regulate
the Salvador/Warts/Hippo (SWH) pathway"
Dr. Xinwei CAO "The Hippo Pathway in Neural Development:
Orchestrating the Proliferation, Survival, and Fate Choice of Neural
Progenitor Cells"
Dr. Nic TAPON "The Hippo pathway regulates apico-basal
polarity independently of its growth control function"
13:00-14:30
Lunch
14:30-16:00 "3
slide-mini-talks" Discussion
chaired by Dr. Marius Sudol & Dr. Mike Yaffe
Dr. BHAWANA DIKSHIT
Dr. REZA EHSANIAN
Dr.YUTAKA
HATA
Dr.WAN JIN
HONG
Dr.DAE-SIK
LIM
Dr.DAVID ROMANO
Dr.SEKIDO YOSHITAKA
16:00-16:30
Coffee Break
16:30 - 17:30 Introduced
& chaired by
Dr. Thijn Brummelkamp & Dr. Kun-Liang Guan
Dr. Helen MCNEILL "Exploring the biochemical basis of
growth control by Fat, Ex and Dco."
Dr. Kun-Liang GUAN "Regulation of the YAP and TAZ transcription
co-activators by the Hippo tumor suppressor pathway"
17:30-18:30 Short
talk speakers
Dr. Hiroshi SASAKI "The Hippo signaling pathway components
Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm
from inner cell mass"
Dr. Zafar NAWAZ "Tumor suppressor, WWOX1, attenuates
oncogenic YAP1 and WBP-2 mediated ER and PR transactivation functions."
23 April 2009
09:00-10:00 Introduced
& chaired by
Dr. Eric O'Neill & Dr. Helen McNeill
Dr. Giovanni BLANDINO "YAP bridges p73 and PML pro-apoptotic
pathways"
Dr. Yosef SHAUL "A Mechanism of Switching of Yap from pro-Oncogene
to Potential Tumor Suppressor"
10:00-10:30 Short
talk speakers
Dr. Subhama BASU "JNK phosphorylates YAP to regulate
stress signaling"
Dr. David MATALLANAS "Regulation of the MST2 pathway
by K-Ras"
10:30-11:00
Coffee Break
11:00-13:00 Short
talk speakers, chaired by Dr. Kieran Harvey
Dr. Yael AYLON "The Lats2-Mdm2-p53 tumor suppressor axis"
Dr. Elmar SCHIEBEL "Function of the Hippo pathway at the
human centrosome"
Dr. Juniichi SADOSHIMA "Inhibition of Endogenous Lats2
Promotes Hypertrophy and Decreases Apoptosis in the Postnatal Heart"
13:00-15:00
Lunch
15:00 - 16:00 Introduced
and chaired by
Dr. Tobias Schmelzle & Dr. Rami Aqeilan
Dr. Thijn BRUMMELKAMP "How the size that tissues and
organs reach during development is controlled"
Dr. Hugo STOCKER "New Signaling Partner of Expanded and
Merlin"
Dr. Eric O'NEILL "RASSF1A/MST2 pathway and the DNA damage
response"
16:00 Dr. Sabrina
STRANO, & Dr. Marius SUDOL
Concluding remarks and discussion panel
|
