2 november
13.00-15.00 registration
15.30 Welcome:
Prof. Paola MUTI, IRE Scientific Director,
Dr. Emilio CIANFANELLI, Mayor Ariccia
Chair: Gianni Del Sal
16.30 Opening Lecture by Moshe Oren
18.00-19.00 Guided Tour of Palazzo Chigi

3 november 
Chair: Giovanni Blandino
09.30-09.55 Nick Tapon "Mapping the Hippo pathway using RNAi screening approaches in Drosophila"; (for the first 10 minutes will introduce the FLY HIPPO PATHWAY)
10.00-10.25 Doujia Pan "Hippo signaling in Drosophila and mammals"; (for the first 10 minutes will introduce the MAMMALIAN HIPPO PATHWAY)

10.30-11.00 COFFEE BREAK

Chair: Jeff Wrana and Xin Lu
11.00-11.12 Philip Karpowicz "The Hippo tumor suppressor pathway requires JAK/STAT                                                     activity to regulate tissue stem cell regeneration";
11.15-11.27 Liselotte Angus "willin/FRMD6 expression activates the Hippo signaling pathway";
11.30-11.42 Joseph Kissil "Angiomotin - a novel mediator of NF2’s tumor suppression function";
11.45-11.57 Todd R. Heallen "Hippo and Wnt/b-catenin Signaling in Cardiac Organ Size Determination";
12.00-12.25 Helen Mc Neill "Dissecting roles of Fat cadherins in flies and mice";
12.30-12.55 Kenneth Irvine "Growth control by the Fat-Hippo pathway in Drosophila";

13.00-15.00 Lunch

Chair:  Helen McNeill
15.00-15.25 Georg Halder "Modulating F-actin organization induces organ growth by affecting 
 the Hippo pathway";
15.30-15.55 Kieran Harvey "The Salvador-Warts-Hippo pathway in tissue regeneration";
16.00-16.12 Laura A. Johnston "Evidence for regulatory feedback between Myc and Yorkie that
 stabilizes tissue growth";
16.15-16.27 Radhika Jagannathan "Negative Regulation of the Hippo Pathway by the Ajuba
 LIM family of proteins";
16.30-16.42 Amy D.K. Bui "The Hippo Pathway Effector YAP Regulates Cytokinesis";
16.45-16.57 Yael Aylon "The Lats2 tumor suppressor augments p53-mediated apoptosis by  promoting the nuclear proapoptotic function of ASPP1";

17.00-17.30 COFFEE BREAK

Chair: Michael Yaffe
17.30-17.55 Junichi Sadoshima "miR-206 Mediates YAP-Induced Hypertrophy and Survival of 
18.00-18.25 Dae-Sik Lim "The Hippo-Sav-YAP Axis is required for the inhibition of hepatic oval  cell proliferation and liver tumorigenesis in mice";
18.30-18.55 Jeff Wrana "Integrating Hippo and Morphogen Signalling Pathways";

19.15-20.00 CONCERT:
Iioria Agostini: Flute
Aldo D'Amico: Cello
Cristina Carini: Piano
program will be announced



4 november
Chair: Moshe Oren
09.30-09.55 Gerd Pfeifer "Loss of Rassf1a enhances p53-mediated tumor predisposition and accelerates progression to aneuploidy";
10.00-10.25 Eric O’Neill "The  role  of  tumour  suppressor rassf1a in the mst2/lats  pro-
apoptotic pathway";

10.30-11.00 COFFEE BREAK

Chair: Yosef Shaul
11.00-11.12  Norikazu Yabuta "Lats1DN/DN MEFs expressing the N-terminal truncated Lats1                                                          protein showed mitotic defects and formed tumors in nude mice";

11.15-11.27  Hiroshi Nojima "An Aurora-A–Lats2–Aurora-B pathway is required for accurate  mitotic progression";

 11.30-11.42 Yutaka Hata "Preparation of tumor-initiating cells using the mutants of TAZ and  YAP";
11.45-11.57 Hiroshi Sasaki "Position-dependent Hippo signaling controls cell fates in preimplantation mouse embryos and is regulated by cell adhesion         
and polarity";

12.00-12.25  Brian Hemmings "The HIPPO-NDR Connection";
12.30-12.55  David Matallanas "; K-Ras transformation requires shutdown of the MST2 pathway and EGF receptor signalling in colorectal cancers";


13.00-15.00 Lunch

Chair: Kieran Harvey and Silvia Giordano
15.00-15.25  Subham Basu "Posttranslational modifications and protein interactions determine
YAP signalling outcome";
15.30-15.55  Henning Wackerhage "Does Yap have a role in controlling the balance between
self-renewal and differentiation in muscle stem cells?";
16.00-16.12 Rami I. Aqeilan "Negative Regulation of the Hippo Pathway by the E3 Ubiquitin Ligase ITCH Promotes Tumorigenicity";
16.15-16.27 Uri Gat "An evolutionary study of Yap and the hippo pathway";
16.30-16.42 Chad Hall "The Hippo Pathway Effector Yap is an Ovarian Cancer Oncogene as  Revealed by nY/cpY Analysis";
16.45-16.57 Siew Wee Chan "WW Domain-mediated Interaction with Wbp2 is Important for the Oncogenic Property of TAZ";
17.00-17-12 David D. Moore "Combined deletion of the nuclear receptors FXR and SHP  activates YAP targets and induces liver tumors";
17.15-17:27 Marius Sudol "YAP is the effector of the HIPPO pathway and uses its WW domains  & PDZ binding to regulate apoptosis or proliferation";




Chair: Georg Halder
17.45-18.10    Xin Lu "ASPP2: Tumour suppression through the control of polarity and  proliferation";
18.15-18.40    Yosef Shaul "Modulation of Hippo Signaling by Tyrosine Kinases";
18.45-19.10    Giovanni Blandino "Role of Yap in Apoptosis and senescence as Tumor  Suppression Mechanisms";


21.15 DINNER in traditional "fraschetta


5 november
Chair: Kenneth Irvine
8.30 - 8.55 Kun-Liang Guan "Regulation and function of the YAP transcription co-activator";

9.00 - 9.25 Fernando Camargo "The Hippo Pathway’s role in neural progenitor cell                                                       proliferation and survival";

9.30 - 10.45 THREE SILDES MINI-TALKS Chair by Marius Sudol and Kieran Harvey

10.45 – 11.00 Short COFFEE BREAK

11.00-11:20 Michael Yaffe Wrap Up Presentation on Hippo Now and Hippo in the Future
11.30-11:45  Sabrina Strano Formal Good Bye from the Organizers

12:00 Refreshments,

Lunch to be individually arranged by participants.  Departure to the airport


The Second Workshop on the HIPPO Tumor Suppressor Pathway
Palazzo Chigi
Ariccia, Rome, 2-5 November 2010







First Workshop Rome April 2009