3rd International
p63/p73 workshop
18-21 March, 2007 - Complesso Monumentale S.
Michele di Ripa - Rome
Provisional Program
Sunday 18th March, 2007
h. 16.30
Welcome: Institutional Authorities
Chairperson: Giovanni Blandino
Prof. Finazzi Agrò (President University
of Tor Vergata)
Prof Luigi Frati (Vice-President University La Sapienza)
Prof. Francesco Balsano (President Andrea Cesalino Foundation)
Prof. Paola Muti (Scientific Director IRE)
h. 17.00 Keynote
Lecture : Frank
Mc Keon (Harvard Medical School, Boston, USA)
"p63 Through the Ages: the Female Germline
and Epithelial Stem Cells "
Introduced by Massimo Levrero
sponsored by ROC
h. 18.00 Keynote
Lecture: Tak
Mak (University Health Network, Toronto, Canada)
"TA p73 deficiency leeds to tumorigenesis"
"
Introduced by Gerry Melino
sponsored by Active p53 Consortium
h. 19.00
Welcome Cocktail
Monday 19th March, 2007
Session
1
Chairpersons: Y. Shaul and G. Cesareni
| 9.00 | Daniel
Aberdam (Nice, France) "Key role of DeltaNp63a in ectodermal commitment and epidermal differentiation of embryonic stem cells" |
| 9.30 | Gerry
Melino (Rome, Italy) "The Nedd4 Binding Partner 1 (N4BP1) protein is a novel inhibitor of the E3 ligase Itch" |
| 10.00 |
Zhi-Xiong Jim
Xiao (Boston MA USA) |
| 10.20 | Roberto
Mantovani (Milan, Italy) "Reciprocal regulation of p63 by C/EBP delta in human keratinocytes" |
10.40 - 11.10 Coffee Break
Session
2
Chairpersons: X.Lu and
R.Mantovani
|
11.10
|
Elsa
R. Flores (Houston, TX, USA)
"Investigating the roles of TAp63 in tumor suppression and metastasis using mouse models" |
|
11.40
|
Charlotte
Ruptier (Lyon, France)
"DeltaNp63 expression is regulated by p53, DeltaNp63 and beta-catenin" |
|
12.00
|
Sergio
Marchini (Milan, Italy)
"DNp63 expression associates with poor survival in ovarian cancer" |
12.30 - 14.00 Lunch and Poster View
Session
3
Chairpersons: F.Mc Keon and I.Screpanti
| 14.00 | Dennis
Roop (Houston, TX, USA) p63 induces key target genes required for epidermal morphogenesis |
| 14.30 | Alea
Mills (Cold Spring Harbor, NY, USA) To be Announced |
| 15.00 | Rose-Anne
Romano (Buffalo, NY, USA) "Transgenic mice reveal unique roles for DNp63 in epidermal cell lineage commitment" |
| 15.20 |
Filipa Pinto (Boston,
MA, USA) |
| 15.40 | Makoto
Senoo (Boston, MA, USA) "p63 is Essential for Maintenance of Thymic Epithelial Stem Cells" |
| 16.00 | Eleonora
Candi (Rome, Italy) "Role of p63 isoforms in development of epidermis and thymus" |
16.20 - 16.50 Coffee Break
Session
4
Chairpersons: A.Gulino
and P.Amati
| 16.50 | Hans
van Bokhoven (Nijmegen, The Netherlands) "Pattern of p63 mutations and their phenotypes in human ectodermal dysplasia syndromes" |
| 17.20 | Caterina
Missero (Naples, Italy) "Toward an Understanding of The Molecular Basis Of The AEC Syndrome" |
| 17.40 | Antonio
Costanzo (Rome, Italy) "A role for the p63-IKKalpha pathway in the development of ectodermal dysplasias" |
| 18.00 | Maria
I. Morasso (Bethesda, MD, USA) "Dlx3 as a downstream target of p63: possible relevance in the pathogenesis of ectodermal dysplasias" |
| 18.20 | Luisa
Guerrini (Milano, Italy) "p63 regulates the expression of Dlx genes in the embryonic limb buds" |
Tuesday 20th March, 2007
Session
5
Chairpersons: U.Moll and S.Alema
| 9.00 | Akira
Nakagawara (Chiba, Japan) "Specific and redundant regulation of p53 family members in Cancer" |
| 9.30 | Xin
Lu (London, UK) "Crosstalk between p73 and ASPP" |
| 10.00 | Alfredo
Cabrera Socorro (SC de Tenerife, Spain) "p73 in the human central nervous system. New perspectives" |
| 10,20 | Gundela
Meyer (Leon, Spain) "p73, p63 and p53 cooperate in postnatal neurogenesis" |
| 10.40 | David
Kaplan (Toronto, Canada) "A role for p73 in age-related neurodegeneration" |
11.00 - 11.30 Coffee Break
Session
6
Chairpersons: E.Flores and R.Knight
| 11.30 | Ute
Moll (Stony Brook, NY, USA) "p73 suppresses polyploidy and aneuploidy in the absence of functional p53 in "primary cells" |
| 12.00 | Penka
Nikolova (London, UK) "Stability and DNA binding studies of p73 protein" |
| 12.20 | Vivienne
Armbruester (Homburg-Saar, Germany) "Physical interaction between p53/p63/p73 and the novel inhibitor protein of histone acetyltransferases, NIR" |
| 12.40 | Kanaga
Sabapathy (Singapore, Singapore) "A novel role for p73 in supporting cellular growth through c-Jun-dependent AP-1 transactivation" |
13.00 - 14.30 Lunch and Poster View
Session
7
Chairpersons: A.Nakagawara and G.Del
Sal
| 14.30 | Yosef
Shaul (Rehovot, Israel) "p73, Yap and c-Abl are friends in need" |
| 15.00 | Subham
Basu (London, UK) "Yes-Associated Protein (YAP) is critical for c-Jun mediated chemosensitivity" |
| 15.20 | Massimo
Levrero (Rome, Italy) "To be Announced" |
| 15.50 | Thorsten
Stiewe (Würzburg, Germany) "p73 inhibits malignant transformation by limiting anchorage-independent growth" |
| 16.10 | Madhavi
Kadakia (Dayton, OH, USA) "Induction of VDR expression upon DNA damage is p73 dependent" |
16.30 - 17.00 Coffee Break
Session 8
Chairpersons: V.Doetsch and C.Balsano
| 17.00 | Giovanni
Blandino (Rome, Italy) "Reactivation of p73 is dangerous for tumor cells" |
| 17.30 | Francesco
Frasca (Catania, Italy) "Tap73? Increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of mdm2-mediated degradation" |
| 17.50 | Mahvash
Tavassoli (London, UK) "PML is an important component of p73-induced EGFR downregulation and apoptosis in head and neck cancer cells" |
| 18.10 | Paolo
Lunghi (Parma, Italy) "p73 Pathway is activated in MEK inhibitor plus Arsenic Trioxide treatment of acute myelogenous leukemia blasts" |
Wednesday
21st March, 2007
Session 9
Chairpersons: A.Mills and Giulia Piaggio
| 9.00 | Volker
Dötsch (Frankfurt, Germany) "Domain-domain interactions within the p53 protein family" |
| 9.30 | Brent
Derry (Toronto, Canada) "CEP-1: Mother of prevention or mother of invention?" |
| 10.00 | Anton
Gartner (Dundee, UK) "Learning from invertebrates? C. elegans cep-1 pathways" |
10.30- 11.00
Coffee Break
| 11.00 | Andrea
Lunardi (Trieste, Italy) "An in vitro protein interaction profile of Drosophila p53 by small pool expression screening" |
| 11.20 | Casimir
Bamberger (Zurich, Switzerland) "Parcae controlling life in an immortal organism - a novel p53-like protein family in the sea anemone Nematostella vectensis" |
| 11.40 | Horng
Der Ou (Frankfurt, Germany) "Invertebrate p53s use different structural elements to stabilize their oligomeric state" |
Session
10
Chairpersons: Y.Haupt and A.Sacchi
| 12.00 | Jean-Christophe
Bourdon (Dundee, UK) "Loss of p53 isoform expression can be associated with poor survival in primary breast tumours" |
| 12.20 | Selected "to be announced" |
| 12.40 | Elisabetta
Sbisà (Bari, Italy) "p53FamTaG database: a public resource which integrates genome-wide in silico and experimental analyses of p53 family direct target genes" |
13,00 - 13.30
Conclusive remarks
Dr. Marino Nonis
(General Director IFO-IRE)